Use of nonsteroidal anti-inflammatory drugs and survival following breast cancer diagnosis.

نویسندگان

  • Yanli Li
  • Theodore M Brasky
  • Jing Nie
  • Christine B Ambrosone
  • Susan E McCann
  • Peter G Shields
  • Maurizio Trevisan
  • Stephen B Edge
  • Jo L Freudenheim
چکیده

BACKGROUND While there is accumulating evidence that use of nonsteroidal anti-inflammatory drugs (NSAID) decreases breast cancer risk, little is known about the impact of NSAIDs on survival after breast cancer diagnosis. METHODS We assessed whether recent, prediagnostic NSAID use and lifetime cumulative aspirin use before diagnosis were associated with survival among 1,024 women with incident, primary, invasive breast cancer. RESULTS Recent prediagnostic use of aspirin, ibuprofen, and acetaminophen and lifetime use of aspirin up to diagnosis were not associated with either all-cause mortality or breast cancer-specific mortality. Neither dose nor frequency of use was associated with risk. Associations were not different for pre- and postmenopausal women. CONCLUSION In our data, prediagnostic NSAID use and lifetime cumulative aspirin use were not associated with breast cancer survival. IMPACT Our findings do not support a role of NSAIDs prior to diagnosis in breast cancer survival.

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عنوان ژورنال:
  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

دوره 21 1  شماره 

صفحات  -

تاریخ انتشار 2012